Zonegran licensed as monotherapy in epilepsy

Zonegran (zonisamide) has been approved for use as monotherapy for partial seizures with or without secondary generalisation in newly diagnosed epilepsy.

Zonisamide monotherapy is non-inferior to prolonged-release carbamazepine in the treatment of newly diagnosed partial seizures | SCIENCE PHOTO LIBRARY
Zonisamide monotherapy is non-inferior to prolonged-release carbamazepine in the treatment of newly diagnosed partial seizures | SCIENCE PHOTO LIBRARY

A phase 3 double-blind, randomised compared once-daily zonisamide to twice-daily prolonged-release carbamazepine as monotherapy in 583 adults with newly diagnosed partial seizures, with or without secondary generalised tonic-clonic seizures. Treatment was given for up to 24 months.

Non-inferior to carbamazepine

Results showed that 79.4% of patients receiving zonisamide in the per-protocol population remained free of seizures for six months, compared with 83.7% in the carbamazepine group (adjusted absolute treatment difference, –4.5%, 95% CI –12.2% to 3.1%), meeting the criteria for non-inferiority.

Similar safety profile

Similar incidences of treatment-emergent adverse events, including serious events and events leading to withdrawal, were observed in the two arms.

Zonegran is already licensed for use as adjunctive therapy.

View Zonegran drug record

Further information: Eisai

Want news like this straight to your inbox?
Sign up for our bulletins

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Already registered?
Sign in

More from intelog

SGLT2 inhibitors associated with increased risk of lower-limb amputation in new study

SGLT2 inhibitors associated with increased risk of lower-limb amputation in new study

SGLT2 inhibitors may be linked to a doubling in the...

New intelog table helps prescribers choose asthma inhalers

New intelog table helps prescribers choose asthma inhalers

Prescribers can now turn to a handy intelog comparison...

LABA/Corticosteroid Combination Inhalers for the Treatment of Asthma

LABA/Corticosteroid Combination Inhalers for the Treatment of Asthma

Key information on asthma combination inhalers.

intelog Learning's top 25 learning modules in 2018: which topics were the hottest?

intelog Learning's top 25 learning modules in 2018: which topics were the hottest?

Discover the hottest topics in primary care learning,...