Technology Appraisal Guidance No. 376
Source: National Institute for Health and Care Excellence
1.1 Radium-223 dichloride is recommended as an option for treating adults with hormone-relapsed prostate cancer, symptomatic bone metastases and no known visceral metastases, only if:
- they have had treatment with docetaxel, and
- the company provides radium-223 dichloride with the discount agreed in the patient access scheme.
1.2 People whose treatment with radium-223 dichloride is not recommended in this NICE guidance, but was started within the NHS before this guidance was published, should be able to continue treatment until they and their NHS clinician consider it appropriate to stop.
The guidance shown above constitutes Section 1 of the full document. A copy of the full document and a summary of the evidence is available on the Internet at
This guidance represents the view of the Institute which was arrived at after careful consideration of the available evidence. Health professionals are expected to fully take it into account when exercising their clinical judgement. This guidance does not, however, override the individual responsibility of health professionals to make appropriate decisions in the circumstances of the individual patient, in consultation with the patient and/or guardian or carer.
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Enquiries concerning the guidance should be addressed to: National Institute for Health and Care Excellence, MidCity Place, 71 High Holborn, London WC1V 6NA. email:
Radium-223 dichloride for treating hormone-relapsed prostate cancer with bone metastases
Issue Date: January 2016